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One theoretical concern: because TB-500 promotes new blood vessel growth, some researchers question whether it could support tumor vasculature

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TheofilisPSagrisMOikonomouEAntonopoulosASSiasosGTsioufisCet alInflammatory mechanisms contributing to endothelial dysfunction

The VEGFR2 activation also promotes endothelial cell survival, migration, and proliferation, which are the building blocks of tissue reconstruction