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In contrast, M1 polarization resulted in a significant increase in the secretion of the pro-inflammatory cytokine TNF, as well as elevated mRNA levels of TNF, IL1, and the hypoxia-inducible factor HIF1, confirming a pro-inflammatory phenotype (Fig
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That will help define how they design in the future
Gene-editing therapies face future challenges including delivery, safety, and disease heterogeneity, necessitating multidisciplinary strategies to optimize the therapeutic window
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