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Laboratory studies: Early research in animal models showed significant fat-loss effects without adverse metabolic results

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Specifically, ROS can oxidize and inactivate MAPK phosphatases (MKPs), which normally dephosphorylate and deactivate MAPKs

10.1016/j.amjmed.2004.03.039 [DOI] [PubMed] [Google Scholar] 265.Fazal M
