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Description

Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin

A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

I was told to schedule at a hospital which tonight told me they ran out of the 2nd doses and would not be able to schedule me at their site due to the rules which state you can only get your second dose at the same location of the first dose

Moreover, we believe that our provisions are targeted to address specific problems in a manner that will not unduly burden the provider community at large