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In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations of the invention and with one or more cations chosen from Tables 3a and 3b

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In research settings, 5-Amino-1MQ does not show affinity for adrenergic receptors or increase heart rate/blood pressure in the way that compounds like caffeine, ephedrine, or clenbuterol do