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Impaired glucose and lipid metabolism and the development of obesity-related diseases have been found in either hypogonadal men or male rodents with androgen deficiency

[DOI] [PubMed] [Google Scholar] 4.Murray JA, Watson T, Clearman B, Mitros F

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Natarajan N et al (2016) Microbial short-chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

Through multi-metabolite synergies, these natural products target key axes such as AMPK/SREBP-1c (lipid synthesis) and AMPK/mTOR (autophagy), coordinately regulating lipid homeostasis and mitigating hepatic injury (Figure 1)

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