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however, when mice are challenged by ligating the left coronary artery, lack of MR attenuates cardiac dysfunction, cardiomyocyte death, and adverse remodeling [95,96]

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The cytokine TGF- triggers the Janus kinases (JAKs) / signal transducer and activator of transcription (STAT) proteins (JAK/STAT) pathway in certain contexts, while suppressing it in others [49]