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Methods Reagents IGF-1 ELISA kit (MG100) was purchased from R&D (Minneapolis, MN)

Briefly, the ground rice leaf tissue (10 mg) from each treatment group was homogenized on ice in succinate assay buffer (100 L), and then centrifuged at 10,000 g for 5 min

Packaging contents 120 capsules Ingredients per daily dose (=1 capsule) 150mg alpha-lipoic acid

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As of August 2025, we had collected over 27,885 survey respondents who had reported using at least one of Ozempic, Wegovy, compounded semaglutide, Mounjaro, Zepbound or compounded tirzepatide (Extended Data Table 1)

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