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Thus the development of effective inhibitors of IAPP amyloid formation is extremely challenging

Prescription agents (e.g., semaglutide) : Stronger clinical evidence, FDA-regulated, but may carry more systemic side effects

Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity

[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

Furthermore, alterations in lipid peroxidation biomarkers (lipid ROS, GPX4, SLC7A11, ALOX5, and ASLC4) were noted in both the STZ-induced diabetic limb ischemia mouse model and human microvascular endothelial cells under diabetic limb ischemia conditions, indicating a potential role of ferroptosis in diabetic limb ischemia

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