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10.1038/s41418-019-0408-4 Cell Death Differ

This mechanism appears to be similar to Bax/Bak-mediated mitochondrial outer membrane permeabilization in apoptosis [130]

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BMJ 342:d2901

In mature astrocytes differentiated from human induced pluripotent stem cells (iPSC)-derived astrocyte progenitors, ketamine can exert rapid antidepressant effects through the activation of amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptors, and estrogen enhances this effect of ketamine by increasing the gene expression of AMPA receptor subunits

However, it is critical to obtain blood samples for these measurements as soon as possible after the onset of symptoms since elevations are transient