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However, understanding when high B12 levels may become problematic helps ensure safe, evidence-based supplementation under appropriate medical supervision

Because it contains four distinct compounds, protocol design should account for potential interactions between components

This is done because any 30-day periods with an OASIS assessment date in November or December might be part of a simulated 60-day episode that would continue into the following year and where payment would have been made based on the through date

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Also, it is important to point out that "average" levels of the neurotypical group may not necessarily be optimal, as they were on typical western diets that are probably not nutritionally optimal

The method of administration and its duration are determined by the cause of the deficiency and the established therapeutic target [5,6]