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Vitamin B12 is the active corrinoid produced in cultivated white button mushrooms (Agaricus bisporus)

[DOI] [PubMed] [Google Scholar] Chen H., Soroka D.N., Zhu Y., Hu Y., Chen X., Sang S

And glutathione

The introduction of tobacco and tobacco pipe by European traders in South-East Asia (16th-17th century) made it possible to smoke opium and opium laced tobacco [4], whereas the standardization of laudanum, a hydroalcoholic extract (tincture) of opium, in Europe (17th18th century) made it possible to take large amounts of morphine and codeine with a single draught [5]

Vitamin C helps maintain glutathione in its active form, so using both together makes each ingredient work better

Hence, with abundant upstream and downstream effectors, targeting NRF2 signaling pathway can effectively affect ferroptosis