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Furthermore, zinc ions act on the insulin signalling pathway and stimulate lipogenesis and glucose uptake into the adipocytes [9]

Given that PGC-1 is a key regulator of mitochondrial biogenesis and an activator of antioxidant enzymes that protect mitochondria from oxidative stress, and that ferroptosis is characterized by mitochondrial alterations and phospholipid peroxidation, we hypothesized that PGC-1 may play a pivotal role in regulating ferroptosis in MASH

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In the absence of vitamin B12 supplementation, unusually high vitamin B12 levels in the bloodstream may sometimes indicate underlying health conditions, including: 10 Several forms of liver disease, such as acute hepatitis, cirrhosis, and liver cancer Certain blood cancers, including leukemia and polycythemia vera Hypereosinophilic syndrome, a group of blood disorders that may lead to organ damage 11 Does Having High Vitamin B12 Levels Mean Cancer