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It is essential to separate established benefits of B12 replacement from unsubstantiated claims regarding lipotropic combinations

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B.et al (2013)

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Nicotine acetylcholine receptors (nACHRs) (Ni et al., 2013) and using an antagonist of 7nAChR can actually inhibit the proliferation of microglia and reduce the expression of inflammatory factors IL-1 and TNF- (Poorthuis et al., 2009), improves neuronal plasticity in the hippocampus (Motaghinejad et al., 2016), and can treat excitotoxicity at low concentrations (Sieber, 2012)

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These findings support the concept of mitochondria-based interventions as a potential therapeutic strategy for neurodegenerative diseases involving mitochondrial dysfunction

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Some patients are up and about within a few days

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