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Short-term interventions (typically 816 weeks) using clearly prescribed aerobic, resistance, or multimodal training regimens appear to facilitate participant compliance and produce consistent metabolic and inflammatory improvements driven primarily by exercise

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While these agents often spare normal proliferating tissues, they introduce new toxicity patternssuch as dermatologic reactions, QT prolongation, diarrhea, and hepatotoxicityoften linked to the pathways they target in normal tissues