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Without an adherence matrix like PRF, the stem cells are not fully enabled to properly bind and integrate into these orthopedics tissues, but instead tend to undergo a programmed cell death called apoptosis and anoikis

Pregnancy and nursing are practical contraindications due to lack of safety data

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doi: 10.1007/s11095-021-03053-5 [DOI] [PubMed] [Google Scholar] 149.Raghuvanshi A, Shah K, Dewangan HK

This study demonstrates the potential of 3D-printed FPLA scaffolds, with viscoelastic mechanical properties matching those of native IVDs in tension and compression, as mechanically stable and biocompatible biomaterials for IVD replacement

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