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2022;12(1):20088.[DOI] 115

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As experimental evidence, GFAP expression is markedly upregulated in reactive astrocytes during CNS inflammation, a characteristic feature of gliosis observed in AD, resulting in a 1.23.3-fold increase in GFAP levels (Kamphuis et al., 2014)

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Among experts, a clinically meaningful change in ALSFRS-R in clinical trials would be a reduction of about 20% in the slope of rate of decline [34]

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