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10.3390/ph16050762 146 QiY.WanY.LiT.ZhangM.SongY.HuY.et al (2021)
10.1038/nn1876 120 NakamichiN.KambeY.OikawaH.OguraM.TakanoK.TamakiK.et al
It appears that the IL-6 secreted into the blood crosses the blood-brain barrier in endothelial cells, activates microglia, and starts a cascade of inflammatory effects that result in activation of inflammasomes, secretion of IL-1 beta, and other downstream neurobiological changes associated with depression
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Small and large animal models in cardiac contraction research: advantages and disadvantages
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