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Furthermore, NAC normalized the altered GSH levels displayed by these animals in the hippocampus and nucleus accumbens, and it partially rescued the altered expression of post-synaptic terminal network genes found in VPA-exposed rats, such as NR2a, MGLUR5, GLUR1 , and GLUR2 in nucleus accumbens, and CAMK2, NR1 , and GLUR2 in cerebellum

10.2144/00291bm09 62 WhittenW

[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Swerdlow AJ, Cooke R, Albertsson-Wikland K, Borgstrom B, Butler G, Cianfarani S, et al

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Using a mouse macrophage cell line, the authors show that IFN-gamma and endotoxin increase both nitric oxide (NO) production and bactericidal activity

While this idea shows a more complex picture from the popular one where free radicals and oxidants are bad and antioxidants are good, it implies that GSH is an essential molecule not only in acting as an antioxidant but also in the absence of oxidative stress, as an endogenous signaling molecule
