glutathione sepharose wiki | C10H17N3O6S | CID 124886 File:Glutathione.png - Wikimedia Commons

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110 Despite a number of studies that reported somewhat conflicting results regarding the different cardiac phenotypes in response to increased AKT activity, it has currently been recognized that short-term appropriate AKT activation leads to physiological cardiac hypertrophy, while long-term AKT activation or AKT overexpression causes pathological cardiac hypertrophy, interstitial fibrosis, and even heart failure

M., Ismail, N

So clearly there is something else going on

An ABC-type cobalt transport system is essential for growth of Sinorhizobium meliloti at trace metal concentrations

Abbreviations: cfPWV, carotid-femoral PWV