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Ethics statement The animal study was reviewed and approved by the Institutional Animal Care and Use Committees at Nantong University

Ensure a polyphenol-rich diet by increasing dietary intake of vegetables and fruit and ensure adequate antioxidant intake from food

Additionally, individuals with other liver diseases such as metabolic dysfunction-associated steatohepatitis (MASH) or autoimmune hepatitis can be excluded using the critical cut-off value of 15%

Administer intramuscularly twice weekly or as directed by a veterinary surgeon

Lin C, Ma R, Zeng X, Zhang B, Cao T, Jiao S, Chen H, He Y, Liu M, Cai H (2024) Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate

Patriarca, S., et al