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Xanthine was suggested as an intermediate precursor because of purine structure similarities

Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells function and viability

After that, these sections were rehydrated, deparaffinized, and incubated for 15 min in a 3% H 2 O 2 /methanol solution to stop the endogenous peroxidase activity

Increasing/scavenging ROS is potentially applicable treatment, and further studies will help to provide more effective strategies for glioma treatment

Likewise, redox-responsive PEG gates connected via disulfide bridges allowed for controlled drug delivery in intracellular reductive environments [209,210]

S2CID 21577500