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Importantly, fisetin has been identified as a senolytic agent capable of eliminating senescent cells and attenuating the senescence-associated secretory phenotype (SASP), thereby improving tissue function in preclinical models of aging and chronic disease [22,23]

[DOI] [PubMed] [Google Scholar] 110.Rothstein J.D., Van Kammen M., Levey A.I., Martin L.J., Kuncl R.W

Circadian rhythm disorders can cause MASLD, so patients should develop good living habits, including go to bed early, get up early, not stay up late, regular personal work and rest

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By modulating key enzymes and signaling pathways, ROS significantly affects core processes such as glycolysis [168], gluconeogenesis [169], and the insulin signaling pathway [170]