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This might be attributed to the fact that hypermethylation of DAPK attenuates pro-apoptotic signaling, thereby undermining the efficacy of anti-EGFR drugs 675 (Fig

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Protein carbonyls arise upon free radical attack on the protein by four processes (8): 1 ) cleavage of the primary amino acid chain with resultant transient free radicals on both sides of the cleavage point that immediately binds molecular oxygen via radical-radical recombination reactions like those noted above for lipid peroxidation

doi:10.1242/jcs.034199 pmid:19174471 Kumar P, Jha NK, Jha SK, Ramani K, Ambasta RK (2015) Tau phosphorylation, molecular chaperones, and ubiquitin E3 ligase: clinical relevance in Alzheimers disease