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Further studies have found that MPTP induces cellular oxidative stress by indirectly affecting mitochondrial complex I (nicotinamide adenine dinucleotide (NADH) cytochrome c reductase) to block the electron transport chain (ETC), leading to cell death (Poirier and Barbeau 1985) (Fig

Conversely, impairment at any phasewhether due to nutrient deficiencies, impaired elimination, or excessive toxin mobilizationcan lead to toxin accumulation and increased risk for chronic inflammatory and degenerative conditions

Effect of diet composition on insulin sensitivity in humans

DAmato, G., Treatment of allergic diseases with monoclonal anti-IgE antibody, Monaldi Arch Chest Dis, 57:117-119 (2002)

Acta Materia Medica

Diniz, Auburn University, United States Reviewed by Alison Ward, University of Saskatchewan, Canada Gastn Alfaro, National University of Cordoba, Argentina Updates Copyright 2025 Costa, Nascimento, Dans, Gionbelli and Duarte