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B12 is an essential vitamin that you can become deficient in, particularly if you follow a restricted or special diet, if you suffer from certain health conditions or if you are over a certain age

To investigate the metabolite profile of Down syndrome using the model, we began by increasing by 50% the V max of CBS, since the gene for CBS is on chromosome 21 and is expressed at 150% of normal

Bartholomew 2010:259-270)

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Moreover, its long-term efficacy is not clearly established owing to the limited data available in this context

Niranjan A, Jawahar A, Kondziolka D, Lunsford LD