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Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

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Cysteine sulfenylation directs IRE-1 to activate the SKN-1/Nrf2 antioxidant response

Design of such a trial should be given some consideration because the goals here are multiple: first to determine how long the effect would last, second to determine effectiveness of a repeat treatment, and third the general health of the patient and how well they tolerate the repeat treatments

Indeed, the thermolabile MTHFR defect and heterozygosity for CBS deficiency might increase vascular disease risk by respectively increasing the amounts of dietary folate and vitamin B 6 that are needed to prevent hyperhomocysteinemia

doi: 10.4161/auto.8.1.18078 111 BerthelootDLatzEFranklinBS