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In DKD, in response to severe or persistent inflammation, TECs undergo EMT through various signaling pathways, such as TGF-, Wnt/-catenin, PI3K/Akt, JAK/STAT, and Notch pathways (7175)

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Although not as severe as the effects of alcohol, simply being hungover also dulls reaction times and decision-making skills

Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus

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