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Pelacarsen, an antisense oligonucleotide, has produced substantial reductions in Lp(a) in phase 2 studies, and the Lp(a)HORIZON outcomes trial is evaluating whether Lp(a) reduction decreases cardiovascular events (Tsimikas et al., 2020)

Gawali SL, Barick KC, Shetake NG, et al

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Natural killer cells: from innate to adaptive features

Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss

Comprehensive management and close monitoring are crucial to address TMs clinical implications