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118 Moreover, focal ARDS and nonfocal ARDS patients respond differently to mechanical ventilation

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Each enzyme family is characterized by a distinct 3D structure, amino acid sequence, and with regard to the metal-binding cofactor(s) used to support its structural stability and catalytic activity (Case 2017): either manganese (MnSOD), nickel (NiSOD), or both copper and zinc (Miller 2012)

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This activates a response that involves production of ROS, a major bactericidal mechanism, and of soluble mediators (cytokines) whose role is to amplify the host response by recruiting and activating other immune system cells