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Furthermore, a deficiency in zinc markedly impairs the barrier function of porcine endothelial cells [471], making them more prone to leukocyte infiltration and facilitating inflammatory processes [472]

Opioid peptides act in conjunction with opioid receptors, the activation of which can inhibit P38 phosphorylation via PCK and MAPK activation, prevent cell apoptosis, and scavenge free radicals to protect nerve cells (Staples et al., 2013)

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School of Medicine, City University of New York, Bronx, NY 10457, USA

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