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Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metabolic and signaling pathways

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The classic motor symptoms of PD result from selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in a loss of their long axonal projections to the striatum

It works by inhibiting the activity of tyrosinase, the enzyme responsible for melanin production