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In one human study, DSIP did not meaningfully change ACTH or cortisol levels after hormonal stimulation tests designed to activate the stress-response system [8]

PMID 30480763

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Meanwhile, microtubule stabilization protein expressions (MAP-2 and Ace-tubulin) were significantly increased in the co-treatment group relative to the vitamin B12 group, which indicated that vitamin B12-mediated protection was most likely achieved by inhibiting ER stress (Figure 4LN)

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