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Then there is the M2 macrophage state associated with anti-inflammatory effects, tissue repair and remodeling, promotion of angiogenesis, wound healing, suppression of T-cell responses, secretion of cytokines like IL-10 and transforming growth factor beta (TGF-), and expression of arginase 1 (ARG1), VEGF, and CD206 among others, essentially activity to promote tumor progression (56, 58)

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Verkhratsky A, Nedergaard M (2018) Physiology of astroglia

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When incubated with cell lysates, GST tag aggregation was dependent on cellular TG2 expression levels

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