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For patients with more severe or refractory pain, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen reduce prostaglandin-mediated inflammation by inhibiting cyclooxygenase-1 and cyclooxygenase-2, key enzymes in producing PGE2 (Banaszewska et al., 2022)

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According to other studies, when plants experience sulfur and phosphate shortage, miR395 and miR399 are up-regulated [95]

Another important aspect of GSH synthesis, particularly in astrocytes, is its modulation by AMPK (Guo et al., 2018)

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