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doi: 10.7762/cnr.2023.12.4.257 166

*Correspondence: Hee-Gyoo Kang, [email protected] Lee, [email protected] This article was submitted to Mood Disorders, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

5 Al-HilalM.AlsalehA.ManiouZ.LewisF

In cellular cultures, the ALC-induced decrease in oxidative stress occurred not only by exerting a protective effect on mitochondrial structure and functioning, thus making the electron transport chain less prone to electron leak and superoxide production, but also by stimulating the mechanisms of endogenous cellular antioxidants defense [112]

The highest NCDs prevalence from physical inactivity is observed among persons who went on to develop type 2 diabetes, (overall median, 43%), followed by those eventually dying, and those developing colon cancer, coronary heart disease, and breast cancer (overall medians, 43, 43, 42, and 41%, respectively) 3

One severe infantile form (patient 13) presented sudden death at 8 months at home without any available data