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Early concentrations of paracetamol in the brain (33) appear to be well-timed with the period of the rising concentration in various brain structures (33) and coincide with the noted brain damage and with the appearance of generalized seizures in the present study

Extended continuous use beyond 12 weeks may lead to diminishing returns as receptors downregulate

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59 Prospective studies on this topic have focused mainly on normalising serum B 12 concentrations and should be interpreted with caution since the specific goal of treatment in symptomatic B 12 deficiency is alleviating symptoms

Their use remains investigational and should only be considered under medical supervision

doi: 10.1096/fasebj.13.13.1787