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Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

doi 10.3390/nu16040507

Moreover, various abiotic and biotic stress conditions modulate the expression of the enzyme- isoforms differently

To confirm the phenotype changes were driven by OGDHc inhibition, we also treated cells with DM-2OG, mimicking impaired 2-OG metabolism by the OGDHc, and found that, similarly to ML226, DM-2OG increased the CCR7 high CD45RO high population, with a corresponding decrease in the CCR7 low CD45RO high population (Fig

While results are promising, extrapolating dosage and safety to humans remains speculative

Its job is to support appropriate cellular migration and tissue remodeling so repair is not merely fast