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Continuous treatment with anti-BTK and anti-BCL-2 therapies is typically required in the management of CLL, and the success of these therapies is heavily dependent on the emergence of drug resistance over time

Resistance to chemotherapy is usually related to mutations in genes regulating cell apoptosis and increased levels of glutathione (Silva et al., 2019)

Through the thiol groups of the cysteine residues, they form tight complexes with metal ions such as Cd++ , Ag+ , Pb++ , Cu++ , Hg++ , and Zn++ as well as with the semimetal As3 (Fig

Small amounts of foam are normal and will dissipate on their own within a few minutes

Further, GSH reacts with H 2 O 2 (Finley et al

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