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This intervention significantly increased the abundances of Faecalibacterium, Eubacterium, and Bifidobacterium, diversity, and induced broad changes in the host metabolome (131) (Table 3)

"Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents"

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Spiekerkoetter U, Bastin J, Gillingham M, Morris A, Wijburg F, Wilcken B

Psychological factors, GI tract dysfunction, and hormonal changes have been studied as possible causes, but the data are inconclusive
