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C5a can elicit significant increase in TF expression of endothelial cells ( Collectively, TF-initiated coagulation activates the IBMIR with interactions between coagulation, complement system, and immune response promote IBMIR process

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The molecule has to penetrate the stratum corneum (the skin's outer barrier) to reach the dermis where collagen is actually produced

Disclosure Significant portions of this work have previously been published as part of one of the coauthor's master's thesis (Erika K