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These results suggest that the GSH biosynthetic pathway, while essential for mosquito stage development, is not an appropriate target for antimalarials against blood stages of the parasite

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Complex formation between glutathione GSH and PrfA is mediated by van der Waals contacts and hydrogen bond interactions, whereby the glutathione molecule interacts with amino acids from both N- and C-domains, as well as the linker region (Fig

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Default mbondi3 radii was used, consistent with implicit solvent models