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Theres research showing, quite a few research papers, that aluminum is directly associated with slowing this gene down

Mistry V

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Similarly several months exposure to ozone or to a prolonged oxidative stress due to a chronic inflammatory disease (atherosclerosis, diabetes, cancer) can possibly raise 4-HNE plasma levels up to 5-20 M and, in spite of continuous detoxification, they can exert pathological effects as those observed in vitro studies performed with leukemic cells [39], lens epithelial cells [40], Jurkat T cells [41] and when testing cholesterol secoaldehyde (CSeco) in cardiomyoblasts [31]