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Many studies have found that there are purine metabolism abnormalities in RA patients and animal models, which are manifested by the increase of the end product uric acid level (Lee et al., 2016
analysis is difficult because there are more than 700 possible mutations 153,154 (ref: and many patients are compound heterozygotes
The most significant enrichment terms for GO were COP9 signalosome, protein deneddylation and azurophil granule lumen (Fig
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Dzierzewicz, Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts
