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doi: 10.1016/j.cbpb.2008.08.009

In the hippocampus, A can induce the activation of COX-2 and Bax, and inhibit Bcl-2, cAMP response element binding protein (CREB), BDNF, and TrkB, while naringin can attenuate these effects of A (Choi et al., 2023)

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The timing and severity of menstrual changes depend on starting weight, rate of weight loss, underlying metabolic conditions, and baseline hormone levels