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NO reacts with superoxide anion (O 2 ) to form a stronger oxidant identified as peroxynitrite anion (ONOO )

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Its effects are largely studied in controlled or experimental settings, and broad clinical validation is limited

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Representative immunohistochemistry (b) and immunofluorescence (c) staining of indicated proteins in Gclc WT and Gclc KO mammary tumors (Scale bar = 50 m)

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AC, Atherogenic Coefficient

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