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The cytosolic GST enzymes comprise the largest family and based upon amino acid sequences and substrate specificities this family has been divided into seven subclasses identified as alpha (, A), mu (, M), omega (, O), pi (, P), sigma (, S), theta (, T), and zeta (, Z)
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The best evidence arises from the studies of the ALDH2 mutation (E487K), which causes an accumulation of acetaldehyde in the presence of ethanol
LiZYLuGQLuJWangPXZhangXLZouYet alSZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice
However, it is important to consume them in moderation as they can contribute to weight gain if consumed in excessive amounts 4
