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The rhGH replacement therapy has also been shown to reduce urea excretion, urea flux, and urea production rate while enhancing protein synthesis and promoting growth and development in children with GHD

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The most common symptom, and usually the first to appear, is watery diarrhea

Furthermore, histone acetylation was decreased by IDH1 inhibition in Xenopus egg extracts (Extended Data Fig

Knight KR, Chen L, Freyer D, Aplenc R, Bancroft M, Bliss B