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(2010) utilized IGF-1 and its analogs to investigate the relative contributions of PI3K/Akt versus MAPK/ERK signaling in IGF-1R-mediated cellular responses, demonstrating context-dependent pathway utilization across different cell types

doi: 10.1073/pnas.0804226105

EGCG: anti-angiogenic effects: The formation of new blood vessels through angiogenesis is a process essential to cancer invasion and metastasis

Meanwhile, MR can also downregulate genes involved in an inflammatory response and immune cell infiltration, such as chemokine receptor (CCRs), chemokine ligand 7 (CCL7), IL-1, IL-6, IFN-, and TNF-

Raghu, G., Berk, M., Peter, Campochiaro, P

In humans, they function as regulators of transcription factors, apoptosis, and immunomodulation (Arner and Holmgren, 2000)