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In addition to its synergistic effects with TNF, IL-17 suppresses melanogenesis through ROS-dependent autophagic melanocyte apoptosis and stimulates keratinocytes to secrete IL-1 through the nuclear factor-B (NF-B)/ROS/ NLR Family Pyrin Domain Containing 3 (NLRP3)/caspase 1 pathway 152
While all animal cells are capable of synthesizing glutathione, synthesis in the liver is essential
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